The chondrocytes in the cartilaginous model’s center grow in size as more matrix forms. Nutrients should not reach the chondrocytes as the matrix calcifies. It causes them to die and the cartilage around them to disintegrate. The resulting voids are invaded by blood vessels. It not only enlarges the cavities but also conveys osteogenic cells, many of which will become osteoblasts. The medullary cavity will form by the merging of these expanding areas. Capillaries pierce the cartilage as it matures. The perichondrium begins to change into the bone-producing periosteum as a result of this penetration. Ossification initiates at the primary ossification center. It occurs in the third month of the fetus when bone cell growth and ossification accelerate. Simultaneously as these fundamental alterations are taking place, chondrocytes and cartilage will constantly grow. The epiphyses involve lengthening the bone, as bone replaces cartilage in the diaphysis. Then the fetal skeleton will entirely form. The cartilage is present on the exterior layer of the joint and within the diaphysis and epiphysis. This sequence of events occurs in the epiphyseal regions after birth. These activity centers are secondary ossification centers.
Bone remodeling is a lifetime process that involves the removal of old bone from the skeleton, known as bone resorption, and the addition of new bone known as ossification or bone creation. Remodeling is the process of:
Continuously removing discrete packets of old bone.
Replacing them with a newly generated proteinaceous matrix.
Then mineralizing the matrix to form new bone.
These systems also regulate bone remodeling and replacement throughout growth and the consequence of traumas such as fractures and microdamage. It reduces the accumulation of microdamage to the bones by replacing old bone with new bone during regular exercise.
Remodeling further reacts to the operative requirements of mechanical loading. As a result, bone is added where it is required and taken away where it is not needed. This mechanism is necessary to maintain bone strength and mineral balance. The skeleton is a metabolically functioning body part, which is constantly reshaping during life. This remodeling is required to maintain the skeleton’s structural integrity and its metabolic functions as calcium and phosphorus storage. The remodeling cycle is strictly regulated to ensure balanced resorption and creation. The systemically produced variables have a role in regulation. The remodeling occurs at several anatomically diverse locations simultaneously suggests that remodeling regulation is essential for establishing this delicate balance. There are three pathways:
The receptor activator of NF-ÎºB ligand (RANKL)
Receptor activator of NF-ÎºB (RANK)
These pathways transduce both systemically and locally generated signals. Because of their regulatory role in regulating the balance and timing of bone resorption and production during the remodeling cycle, they could be helpful targets for pharmaceutical therapies in diseases like osteoporosis.
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